A naturally occurring single residue mutation in the translocator domain of 1 Neisseria meningitidis NhhA affects trimerization , surface localization
نویسندگان
چکیده
7 1 Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy 8 2 Centro Interdipartimentale di Microscopia Elettronica, University of Tuscia, 01100 Viterbo, 9 Italy. 10 11 12 Running Title: Natural mutation in the translocator domain of NhhA 13 14 * Corresponding author: Beatrice Aricò, Novartis Vaccines and Diagnostics 15 Via Fiorentina, 1 16 53100 Siena, Italy 17 Tel: +39 0577 243239 18 Fax: +39 0577 243564 19 E-mail: [email protected] 20 21
منابع مشابه
A naturally occurring single-residue mutation in the translocator domain of Neisseria meningitidis NhhA affects trimerization, surface localization, and adhesive capabilities.
Neisseria meningitidis NhhA (Neisseria hia/hsf homologue A) is an oligomeric outer membrane protein belonging to the family of trimeric autotransporter adhesins. NhhA mediates the interaction of N. meningitidis with human epithelial cells and components of the extracellular matrix. The recombinant protein is able to induce bactericidal antibodies and hence has also been considered a potential v...
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